IgG Food Antibodies

The IgG Food Antibody Assessment (*not available in NY) is a blood test that measures antibodies to 87 commonly consumed foods. The panel also includes a total IgE measurement. The body can react to foods in many different ways. Adverse food reactions can lead to distressing symptoms and chronic health conditions. Often times it is unknown exactly which food(s) may be the cause and testing can help identify the problematic foods. Removal of the reactive foods often results in resolution of symptoms.

What is the difference between IgE and IgG-mediated reactions?

There are some key differences between IgG sensitivities and IgE allergies. A few of those are summarized below: - 

1. IgE-Mediated Allergies include Foods, moulds, and inhalants. In the case of Mediated Sensitivities spices, and vegetarian foods are included.
2. Immediate onset (minutes to an hour) can be seen in the case of IgE-Mediated Allergies, whereas Delayed onset (hours to days) for IgG-Mediated Sensitivities.
3. IgE-Mediated Allergies circulate for a half-life of 1-2 days and Circulating half-life of 21 days for IgG-Mediated Sensitivities.
4. Permanent allergies treatment can be seen in the case of IgE-Mediated Allergies and Temporary sensitivities for IgG-Mediated Sensitivities.
 5. IgE-Mediated Allergies Stimulates histamine release and IgG-Mediated Sensitivities Does not stimulate histamine release.

When should testing for IgG Food Antibodies be considered?

Testing for adverse food reactions is useful for individuals who suspect that a food is responsible for causing their symptoms, but can't quite identify which food(s).
The presence of circulating antibodies may affect each patient differently. Circulating IgG food antibodies are not diagnostic for a specific condition, but indicate an immune response to that food. The immune response could be a normal response that would not necessarily cause symptoms. Therefore, test results should always be viewed in the context of the overall clinical picture. The role of IgG food antibody testing is still being researched, however, studies have shown the benefit of testing in certain conditions.

Some of the conditions associated with IgG food sensitivity are: -

1. Obesity
2. Joint aches
3. Crohn’s Disease
4. Migraine headaches
5. Autoimmune disease
6. Major Depressive Disorder
7. Skin rashes such as eczema
8. The “Leaky Gut” Connection
9. Irritable Bowel Syndrome (IBS)

Increased intestinal permeability lead due to the presence of circulating IgG antibodies to foods, this is also referred to as “leaky gut syndrome.” Large substances can leak through the tight junctions as the barrier formed in the gut don’t work properly and thereby causing an immune response. The production of IgG antibodies in foods may be due to the improved immune response. 
Any contribution to increased intestinal permeability includes various lifestyle factors and multiple dietary. Chronic NSAID use, stress, alcohol consumption, a western-type diet that basically includes high sugar, low fibre food, red meat, and animal fat. In addition to this prolonged and strenuous exercise will have a certain impact. 

Ordering the test: - 

It is up to the patient to decide whether The IgG Food Antibody Panel will be considered as a bundle with other profiles or to be ordered as a stand-alone test. Clinical experts in most time will advise going with the bubbled pack as it will bring out a clear cut idea of the patient’s immune-mediated response. Several small profiles will be included to form a bundle. 

What advantage does the IgG Food Antibody test offer compared to other diagnostics?

There might be some delay in response to food as IgG food antibodies are present. Immediate hypersensitivity to a substance is possible due to IgE antibodies. In most cases, it has been seen that the patients and the clinicians can easily detect the type of food that causes an immediate response. It is true that testing can be helpful but challenges will be there in case of delayed response to food. The assessment IgG versus only testing for IgG(1-4) versus only testing for IgG4. IgG4 testing is available for a specific component of IgG.
The conditions for IgG testing and clinical symptoms are now correlated with the continuous body of scientific evidence. In earlier days, cell size testing for identifying food sensitivities was considered as a thumb rule but with the advancements in the field of medical science, it has been proved that IgG ELISA testing is more reliable and consistent.
Lymphocyte response assays and Antigen leukocyte antibody testing (ALCAT) are the most profound examples of cytotoxic testing or cell size testing.
Food intolerances are the types of adverse food reactions that the immune system does not maintain. One of the most common examples of food intolerances includes lactose intolerance. This is caused due to lactase enzyme deficiency in the gut. Suitable tests are now available for suspected lactose intolerance but not for all food intolerances.
Other food intolerances may include nightshades, salicylates, oxalates, vasoactive amines like tyramine and histamine, FODMAPs, lectins, and food additives and preservatives such as aspartame, nitrates, MSG, sulphites, etc. The elimination of diet remains in terms of standardization and identification of symptom-producing foods as testing is not available for every type of adverse food reaction. 

IgG Antibody Testing: -

At Biogenie we have introduced semi-quantitative serum levels of IgG antibodies to foods by the use of the sandwich ELISA method to test food antibodies. A semi-quantitative level can determine the degrees of igg test UK present for each food. The followed levels are High (+3), Low (+1), VL (very low), Moderate (+2), and Negative (none detected). 
In order to assess IgG antibody responses, we have considered epitopes as partial proteins in making these assessments. Some specific foods are there that get identified due to the protein portions that are designed by epitopes. For the detection of IgG antibodies to food antigens, there are no standardized, FDA-cleared laboratory assays available in the US market. Biogenie uses commercially-prepared antigens so that the IgG food antibody assessment can be carried out. The World Health Organization of International Standard has standardized the levels of IgG reactivity.
At Biogenie we utilize 3gAllergy Specific IgE Universal Kits, FDA-cleared Siemen's, and  IMMULITE 2000 Total IgE. The solid-phase Chemiluminescent assay constitutes the Immulite® 2000 Total IgE. It exploits liquid-phase kinetics in a bead format as it is a solid phase with a two-step chemiluminescent immunoassay. We can receive increased sensitivity by enhancing the chemiluminescent signal whereas the proprietary wash technique enhances specificity.

What can clinicians and patients expect from IgG Food Antibody testing?

In general, it has been observed that the elimination and rotation of highly reactive foods come under clinical management with food sensitivities. Diet modifications play a crucial term I’m improving the symptoms. After several weeks or months of elimination, the patient may be required to tolerate the amount of food intake.
The leaky gut or  Increased intestinal permeability may simultaneously be addressed with botanicals, nutraceuticals, diet, as well as by modifying the contributing factors.
You will get your igg testing for food allergies done in no time   You can also visit our IgG, IgE, and Celiac Tests Prep page in case you find any difficulty.
This page will help you learn about medications that may impact paediatric testing, length of exposure to antigens, impact test results, and diseases that may affect antibody levels. At Biogenie we will always be there to guide you and help you in recovery. We will serve you till the end as you recover from the trauma.