Organic Acids (Formerly Metabolic Analysis Profile)

In order to measure organic acids, it is recommended to collect the first-morning void (FMV) urine. A nutritional test will be carried on it that is known as Metabolic Analysis Profile or on paper as organic acid testing. The vitamin and mineral cofactors are through the report that includes personalized micronutrient recommendations. This report also depicts the patient’s biochemical metabolism as recommended through digestive support.
During the fundamental metabolic processes of our body, compounds are formed with broader classifications, termed organic acids. The digestion of carbohydrates, dietary protein, and fat collaboratively form these compounds through metabolic reactions. There are mainly two functions that are carried out from the organic acids, the first one is the generation of cellular energy and the other one provides many of the building blocks necessary for cell function. The functional assessment of nutrient status is offered by urinary organic acid measurement.

What is a functional nutritional assessment?

A significant accumulation of organic acids in the urine can indicate metabolic inhibition. Inherited enzyme deficiency, toxic accumulation, nutrient deficiency, or the action of a drug may result in the metabolic blockade. Vitamins and minerals are the enzymes responsible for the metabolism of organic acids. Thus, it can be said that the increase in organic acids may reflect a functional need for these nutrients at the biochemical and cellular levels, despite normal serum levels.
Nutrient supplementation is based on recommendations that have high organic acid results and are generated using a proprietary literature-based algorithm. The assessment of acidity has been used in pediatric or neonatal medicine that is used in the identification of congenital genetic errors in metabolism. In order to carry out the severity, it is essential to work on the type and degree of error.
In most cases of congenital genetic errors, it has been observed that the enzyme defect can be compensated by using high-end doses of specific vitamin and mineral cofactors or by dietary interventions. These interventions with nutritional cofactors at higher doses may also be effective in cases of reduced enzyme activity that are caused other than congenital errors. We make sure that the general public must be well aware of the fact that My Biogenie’s organic acid testing is not intended for the diagnosis of pediatric or neonatal inborn errors of metabolism.

Who All Are Going To Get The Benefits From My Biogenie’s Organic Acid Testing?

We claim that our organic acid test interpretation will be effective for patients with fatigue, inflammation, chronic stress, mood disorders, and mitochondrial dysfunction. Neurocognitive decline, anorexia, depression, diabetes, cardiovascular disease, cancer, anxiety, and other such diseases are associated with abnormal organic acid levels.

How Organic Acids Test Works?

In order to carry out clinically actionable results and easy interpretation, it is essential to have organic acids report. You will get personalized recommendations after a thorough analysis of organic acid test UK NHS results. Your recommendations may incorporate supplement schedules, lifestyle changes and other modifications if required. The report also mentions facts related to nutrient function, complications and causes of dietary sources and their deficiencies. You will also find categorized test results in the metabolic analysis profile into major metabolic areas. Those are: –

1. Oxalate Markers: –

Some higher levels of oxalic acid will ultimately result in the glycosylation pathway due to the presence of oxalate markers that may provide insight into abnormal metabolism. People suffering from recurrent kidney stones will get specific references as oxalates may have specific clinical relevance to patients. The development of kidney stones is a strong risk factor due to the appearance of high levels of oxalic acid.
After numerous researches, we have come to the conclusion that the dysfunctional oxalate metabolism may result due to the increased levels of oxidative stress and metabolic dysfunction. This also results in higher excretion of oxalic acid.

Vitamin Markers: –

In order to assess the status of specific B-vitamins, it is essential to have commonly used organic acids. This can be achieved by measuring organic acids that are known to rely on specific nutrients in order to carry out enzymatic metabolism.

Neurotransmitter Metabolites: –

The organic acid compounds of neurotransmitter metabolites are considered as the downstream metabolites of degradation and neurotransmitter synthesis. Altered neurotransmitter metabolism can be represented by elevations due to genetic predispositions, stress, chronic illness, enzymatic nutrient cofactor needs, and toxins.
Toxin & Detoxification Markers: –

Exposure to environmental toxins can easily be reflected by toxin and detoxification markers. Up-regulation of detoxification pathways are carried out in response to exposures. The recommendations from elevations were forwarded to identify the exposures so that they can either be minimized or removed. In order to detoxify the pathways, specific clinicians may consider the use of nutritional support and antioxidants.
Malabsorption and Dysbiosis Markers: –

Fermentation of flavonoids and dietary phenols take place in the GI tract along with fungal and bacterial activities to develop by-products in the form of markers. A healthy intake of antioxidant-rich foods will get reflected in the absence of dysbiosis and high levels of available metabolites. It is wise to go for a stool test for more information regarding GI dysfunction and dysbiosis after the elevation of multiple markers.
Cellular Energy & Mitochondrial Markers: –

Our body’s ability to process dietary macronutrients get reflected through mitochondrial markers and cellular energy. Easy identification of mitochondrial disjunction cycle and oxidative stress can be seen in the Krebs cycle for subsequent energy production. Some abnormalities such as functional nutrient insufficiencies, genetic polymorphisms, enzymatic dysfunction, toxins, and underlying diseases come across the Krebs cycle.
These can also be seen in protein metabolism, fatty acid oxidation, and glycolysis. Various clinical conditions were symbolised due to the abnormal urinary excretion of these organic acids, and potential therapeutic targets to correct mitochondrial dysfunction.
Our Methodology: –

LC/MS/MS, alkaline picrate, and GCMS are some of the most common methods to measure urinary organic acids. Before the procedure, a questionnaire-qualified healthy cohort must be taken into account. This mainly includes gender and age. If the patient is under 2 years old, the organic acid test UK is not performed.
Netravali Plasma profile and NutrEval FMV comprehend the organic Acids as an integral part. Organic acid measurement is not the only nutritional test that is carried out by NutrEval. Elemental markers in the form of both toxic and nutrient elements, essential and metabolic fatty acids, amino acids, and oxidative stress markers can also be performed. Metabolomix+ urine nutritional test includes organic acids as its vital component and in addition to organic acids, it also measures oxidative damage markers and amino acids.